Welcome to iRV2 .
Yes proper tire inflation for your coaches weight and tire brand, is very important . So the first thing to do is get your : loaded for travel : corner weights if possible . Corner weights , because you inflate all tires on the axle to the correct inflation for the heaviest loaded tire(s).
Setting tire weights to 1/2 the loaded axle weight can led to one side tire (s) over inflated and one side under.
With inflation correct then you can look to other possible causes , shocks, alignment , etc.
One big thing I had to correct on my coach , was the drivers seat was not centered behind the steering wheel , and that gave me shoulder pain after a long drive , had to move the seat 1" to the right, to correct.