While your waiting for the Alpine experts to come to your aid I will toss a few things out there.
Will have to check in the morning but I am sure there is a flashing LED on my silverleaf box. So make sure it is blinking. If not maybe you have a fuse blown somewhere in data line.
Click on the Advanced tab and make sure you have the proper engine selected.
Click on the advance tab and select communications. You might try a different port but first move the USB cord to a different input. Sometimes you might get a USB connection that does not work good in certain cases.
Each time you change something, port or input connection, press the "restart port" button on the comm tab.
Make sure you have the proper drivers installed!!!!
All I can think of right now.
Make sure engine is running during checks
98 Endeavor DP, ISB275
RX300, Falcon II hitch, BB Vantage Select
VMSpc, 2002 Grey Ford Powerstroke
TST 507 w/ 10 Sensors