We have the ducted AC and engine driven OTR AC.
We also have the single pane windows. I installed a home theater 5.1 speaker system years ago. Standing outside 5 feet away from the rig with all the windows and door closed, I could barely hear the car and tree sequence from a Harry Potter movie which was quite loud inside the rig.
I would guess the double pane benefit is more about less condensation and heat retention than noise reduction. But, I have not one of each type of window setup to compare....
1995 CC Magna #5280
C8.3L 300hp Cummins, 31,000lbs