Hi Ted and Welcome to the Forum!
I've got good news and bad news for you.
The good news is your 460 has little in the way of smog equipment on it. Just an AIR pump which doesn't do much as far as affecting power or mileage. No catalytic in the exhaust on that era F53 - what you may see that looks like a cat is just a "resonator".
The bad news is there isn't much you can do to improve mileage on a 460 powered, 36 foot Class A. At a minimum, you could replace the factory muffler with something that flows better. The Ford muffler is VERY restrictive.
Next level is headers and full exhaust. You'll see much better power but you're still not going to see a big jump in mileage. MAYBE 1 MPG if you can keep your foot out of it.
Sorry, but that is the tale of woe with our big gassers.