I have not done it on the F53 but here is the way the book says to do it.
Radiator and Fan Shroud, F-150-250-350, F-Super Duty Chassis Cab and Motorhome Chassis with Gasoline Engine
Removal
1. Drain the cooling system by removing the radiator cap and opening the radiator drain cock located at the lower rear corner of the radiator tank. To prevent coolant loss when draining radiator, slip a hose on the radiator drain cock and drain coolant into a clean container.
2. Remove the rubber radiator overflow hose from the radiator coolant recovery reservoir and detach it from the radiator.
3. Remove the two upper attaching screws, lift the fan shroud out of the lower retainer clips and drape it on the fan. On F-Super Duty Motorhome Chassis vehicles remove the two screws at the bottom of the fan shroud.
4. Loosen the upper and lower hose clamps at the radiator and remove the upper radiator hose and lower radiator hose from the radiator connectors.
5. Remove the heated water bypass hose (E4OD-equipped vehicles only) located directly below the overflow nipple on the radiator outlet tank.
6. Disconnect the two automatic transmission (if so equipped) oil cooling lines from radiator fittings.
7. Remove the two radiator upper attaching screws or bolts.
8. Tilt the radiator back approximately 25mm (one inch) and lift directly upward, clear of the radiator support bracket (8052) and fan blade.
9. If either upper radiator hose or lower radiator hose is to be replaced, loosen clamp at the engine end and slip the hose off the connection with a twisting motion.
10. Lift the fan shroud off the fan and remove from the vehicle.
11. Remove the radiator mounting insulators (8124).
Installation
1. Position the radiator mounting insulators to the lower frame.
2. Position fan shroud on fan until radiator is installed.
3. If either upper radiator hose or lower radiator hose has been replaced, install on engine with index arrow in line with mark on fitting on engine. Install double wire clamps and tighten to 3-4N-m (27-35 in-lb).
4. Install the heated water bypass hose (E4OD-equipped vehicles only) to the nipple located below the overflow tank.
5. Position radiator into engine compartment to radiator support, being careful to clear fan.
6. Inspect the radiator mounting insulators. Replace if necessary.
7. Install two upper attaching bolts or screws. Tighten to specifications.
8. Connect the two automatic transmission (if so equipped) oil cooling lines to radiator connectors and tighten tube nuts to 16-24 N-m (12-18 ft-lb) or clamps to 4-5 N-m (35-44 in-lb).
9. Attach upper radiator hose and lower radiator hose to radiator. Position hose on radiator connection so that index arrow on hose is in line with mark on connection. Install double wire clamps and tighten to 3-4 N-m (27-35 in-lb).
10. Position fan shroud on the lower retainer clips and attach the top of the fan shroud to radiator with two screw and washer assemblies. On F-Super Duty Motorhome Chassis vehicles install the two lower screws. Tighten screws to 6-8 N-m (53-71 in-lb).
11. Attach rubber radiator overflow hose from radiator coolant recovery reservoir to radiator.
WARNING:
DO NOT STAND IN LINE WITH OR NEAR RADIATOR FAN BLADE WHEN ENGINE IS RUNNING.
NOTE:
A 50/50 mixture of coolant concentrate and water is recommended to maintain best overall performance. To avoid damaging the radiator or engine, the coolant concentrate should not exceed 60 percent.
12. Install new 50/50 mixture of water and Premium Cooling System Fluid E2FZ-19549-AA or equivalent and operate the engine for 15 minutes. Check the coolant level and bring it up to within 38mm (1-1/2 inches) of the radiator filler neck.
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