I believe the "defect" you've discovered on the F53 chassis may have been created by the body builder. I just inspected the shift cable routing on our 2013 Winnebago Adventurer to find the closest it comes to the exhaust manifold is over 10".
Winnebago has installed 2 brackets attached to the body to protect the cable. The cable exits along side the steering column and is immediately run through a bracket. There is a second bracket several inches away that routes the cable along the bottom of the floor. The cable is well past the exhaust manifold when it takes a 45* turn directly to the bracket on the transmission.
When Ford ships the bare chassis to the body builders the wiring harnesses and shift cable are routed over a temporary bracket attached to the drivers side frame rail. If you look at the drivers side picture of the 2014 bare chassis the bracket is visible.
http://www.fleet.ford.com/resources/...2014_LoRes.pdf
This same bracket also appears in the 2011 and 2013 F53 brochures.
The body builders remove this bracket as it would interfere with the engine compartment and fender enclosures. Apparently different body builders have taken different measures to route and protect the harnesses and cables.