I put a Vortech unit on a buddy's 460 Ford Class C, back in the mid 90's.
the gains were less than stellar, but it did work.
Had to run premium, and an electronic spark retard system.
I have a Vortech on my Lincoln Mark VII. works great, but is a whole lot lighter too.
Still need premium, but no spark retard or water injection.
I think, for the M/H usage, it should be a turbo, due to the low speed spooling ability. Like when you are coming out of a 1st gear switchback on a mountain pass. Open the throttle, and the turbo spools up and makes boost even at lower RPM.
Last I heard, 5Star tuning is working on one for the 2 valve V-10 Fords, as I speak.
There goes a years improvement budget.