Most all of your house systems will be identical to your 5th wheel. Water heater, fridge, HVAC, etc..
What you will need to familiarize yourself with is the chassis. Things such as the generator, jacks, electrical switching for coach and house batteries as well as switching between inverter, generator, and shore power. The mechanical aspect is just like changing to a different and larger truck than what you have been towing with. Familiarize yourself with the maintenance of the drivetrain and it's component locations. Also pay attention to your wieghts and tire pressures.
Driving is six of one or a half dozen of another. If you've been towing a 5th wheel that is 36' or larger with a 3/4 or one ton truck there shouldn't be a "large" learning curve. With a toad you are pretty much just reversing the point of articulation. Your turning will be about the same as when you swing wide for trailer clearance and braking distances should be comparable.
Enjoy the "new" lifestyle! I changed from a 36' 5th to a 40' MH about two years ago. I had been towing the 5th for ten years. As stated, no more stopping somewhere for the DW to use the facilities, food is readily available and can be prepared without leaving the warm, dry, or cool comfort of your rig. Also if you travel with children or pets you will not be bothered by them being cramped in the back seat of the truck and complaining about the ride being so long. It all makes for a much more enjoyable trip. I made a 6000 mile trip this summer with several 500+ mile days and not one complaint from the folks riding with me (DW, daughter, and mother).
2007 Newmar Kountry Star 3914, ISL400
2001 Jeep Cherokee toad, M&G brake/2011 Jeep Grand Cherokee Overland