We bought our last coach first - a Holiday Rambler Endeavor 43 DFT. It's 44+ feet long with a tag axle - built on a Road Master RR10R chassis. Aside from the obvious (that being it's a BIG vehicle) - it's a dream to drive. It tracks well - with very little buffeting when near over big vehicles (i.e., semi tractor/trailer rigs). The air suspension makes for a smooth ride.
If you've never driven a large DP ... I suspect you'll find two things that will take some getting used to. First and foremost is the wheelbase and overall size of the vehicle. As the driver, you're sitting slightly ahead of the front wheels - which combined with the wheelbase makes for very different turning angles. It will likely take a little bit of practice before it feels "natural" to you. You'll have to learn to judge the space required to turn your coach around - as well as paying attention to stuff you never would have even thought of while driving your car (like tree branches above and beside you, proximity of street signs to the side of you (and your mirrors!)), etc.
The second thing that will take a little adjustment will be getting used to air brakes. I've become accustomed to using a feather touch in my power brake equipped cars and pickups. With no basis for my expectations - I thought that air brakes would be similarly "touchy". As I discovered the first time I stepped on the brakes in the coach - that's not the case. Stopping a 43,000 pound vehicle will require you put a little leg into it. It's NOT difficult - it's simply a little different. While I often stop my cars and pickup trucks with the big toe of my right foot - I use my whole foot when it's time to stop the coach.
Obviously, a large RV is not a car. However, I think that you'll find that while there is a difference between driving something 30..ish feet compared to driving something 45...ish feet - the difference is nothing more than that ... it's just a "difference". I wouldn't let concerns about driving something that is an extra 5, 10 or 15 feet longer be a determining factor in my purchase.