Out previous motorhome was on the 20,500 lb. Ford F53 chassis with the 19.5" wheels. Our current motorhome is built on the 22,000 lb. Ford F53 chassis with 22.5" wheels.
The new one rides much smoother and quieter than the previous one. I'm not sure the improvement is solely due to the tire size. Like most vehicles there have been a number of other improvements over the years.
Keep in mind however that the GCWR (Gross Combined Weight Rating) for both is 26,000 lbs. Essentially that means on the newer one you can load 22,000 lbs. on the frame, but the maximum amount you can tow (assuming the chassis is loaded to the maximum) is 4,000 lbs..
The older one can only carry 20,500 lbs. on the frame, but the maximum amount you can tow (assuming the chassis is loaded to the maximum) is 5,500 lbs.
2013 Adventurer 32H