We like the E/W bed position far better. We were shopping for a bedroom slide floorplan, but ended up liking our 2000 Winnebago 37G, which does not have a bedroom slide. This has been the only bedroom-without-slide floorplan that we saw and liked, which is saying something because I was adament that I wanted a bedroom slide.
Even without the slide and it being E/W, we can easily walk around the regular sized queen bed while traveling or parked (we have pillow top mattress that didn't come with the motorhome), and the dresser and large sliding door closet is at the back side of the bed. All is always accessible. We also both have adequately sized nightstands (the right side with a larger surface area than the left). I have 4 drawers under mine, and my husband has shelves with a door under his.
The reason that we decided that we didn't like the N/S position is that most of those bedrooms had wardrobes/closets over one or both nightstands. The bottoms of them came down far enough that we thought we would have trouble with bumping into them. Plus, we think that we would feel more "boxed in" with them hanging there. To each his/her own, but there are MANY of us out there that do prefer the E/W layout.