1) For gas, see PilotFlyingJ.com
& get their mobile app for finding locations. Other similar options exist making fueling a non-issue. Plan your fuel stops.
2) when taking off for the day, it'll be nerve racking for a short time. Co-pilot should note this & not engage the driver in chit-chat for 20 or 30 minutes, after which the driver will have sync'd into a more casual attitude.
3) definitely take the toad, etc. per above suggestions
4) Wife tells me the only real hard thing for her to get comfortable with was right turns. We had a retired fireman drive our coach one day, & he gave her this simple instruction, just as he gave to rookies:
~ stay to the left side of the right lane, hug the line if things are tight. This leaves some space to your right side.
~ take as long as you need, use blinkers, if you have to move at 1 mph to move safely then that's your speed and everybody will wait for you to finish.
~ pull straight ahead
(do not turn the wheel) until the line thru your hips coincides w/the curb line of the street to your right you are turning onto. Once you get to this position,
~ turn the wheel to the right lock & proceed onto the new street. Unwind the wheel to adjust to the new street lane position.
~ Gun it. (just kidding)
#4 will be your best starting position for learning. After several successful turns, you'll be doing it by feel. In a parking lot w/sharp cornered landscape planters you may need to pull straight to slightly ahead of the hip-line to avoid running over the imbecile architect's parking obstructions. Running down the road is a snap, only slight lane positioning comfort tricks needed which you will get in class.
Good luck w/your new rig! And visit here often for any Q&A you may need.
Otherwise, just don't head thru any large downtown areas in rush hour traffic (or avoid them if possible regardless of the hour). I drove thru downtown San Francisco surface streets pulling the toad not too long ago, ~11:00a.m. Had the wife on Google Maps to let me know how many blocks till a turn movement. There was plenty of traffic, but everybody stayed out of the way sufficiently that getting onto the Golden Gate Bridge was fairly a breeze. Buses do it after all, right?