I used portable AC unit to supplement the basement air in our RV. It worked well. The draw back is it is kind of large and of a pain to move around or in and out of the RV. Setting it up to exhaust out a window was not a problem. I've since repaired the basement air and added a roof AC so don't carry it in the RV but do use it at home as needed. Bottom line it is not a problem as far as I can tell.
Bob, Sandi & Marmaduke the Big Pug
SW OREGON 2004 Journey 39K, 330 Cat
If towing: a 2006 Mini Cooper or 1995 Wrangler