I like opposing living room slides. Our coach has three slides: opposing living room and one bedroom. My parents have a coach with one living room slide and one bedroom slide, both on the drivers side. They have a recliner behind the passenger seat and if someone is sitting on the recliner and the couch, it is difficult to walk between their legs etc. Just feels a tad crowded(even though it really isn't) With our coach and the two opposing slides, the living room is huge. You can walk down the middle even with people stretched out on both couches.
We prefer an East/West bed but true, with the slide in, we can't access the dresser. Really not a big deal to us. If I had my choice, I would have gotten a coach with 4 slides. We have a DP and with our particular model, there is no under bed storage. Not a bid deal for us as the bedroom has tons of storage elsewhere.
As for the awning, true, it does kind of suck to not be able to angle the awning down. We looked at one coach, an Itasca Ellipse, that had the awnings on the side of the slides, not above them(it still had slide toppers). This made for a much more friendly angle to the awning.
Someone mentioned they liked having the basement storage on the slide. I personally HATE this for two main reasons:
1) you have to be really careful how much stuff you put in the compartments because you don't want to put to much load on the slide mechanism
2) No pass through storage. This is a big one for me cause I like to be able to have the option to carry long things like an outdoor rug or a ladder etc. Our current rig has only one very small pass through storage compartment as the drivers slide has the compartments on it. This was a compromise for me as finances dictated it. If we every upgrade, there will be full pass through storage.
As for structural integrity regarding number of slides in a box etc...I trust the engineers know what they are doing. Just look at minivans nowadays. They have 2 front doors, 2 full large sliding rear doors on each side and the entire rear of the vehicle opens up. THAT's a lot of holes and the structural integrity is fine. All the doors help with structure stay together. Same thing with slides, when they are closed, they become part of the structural integrity.
2005 Winnebago Journey 39K, 350HP C-7 Cat
Toad: Flat deck car trailer hauling a 1932 ford tudor sedan