These are always interesting comparisons. The biggest problem is in getting accurate comparisons. Engines are like big air pumps and the more air they pass, they more fuel they also pass. In an ideal world a small displacement engine turning at slows RPMS would give you best fuel economy. However, you can only move so much weight so that's where the compromises come in.
The big 600 HP ISX in the K3 has a larger displacement engine than the Mountain Master's 450 HP ISL so it's going to move more air. However, there is so much bottom end torque in that engine that it dosn't need to downshift as much so it keeps it's revs lower. Also, the final drive ratio is lower due to the taller rear axle gearing so that also keeps the revs lower during normal cruising speeds. I would suspect that one helps offset the other but probably doesn't completely compensate so the ISX probably moves more fuel through it.
The biggest factor in any fuel calculation is wind resistance. Driving at 10 MPH produces 100 pounds per square foot (PSF) of wind resistance. On a typical motorhome that's 10,625 lbs of resistance due to the large frontal area.
At 55 MPH that goes up to 3,025 PSF, which is around 321,406 lbs of total resistance. Yes, it takes horsepower to move that air out of the way so the fuel usage goes up as the speed increases.
At 70 MPF it goes up to 4,900 PSF, which equates to 520,625 lbs of total resistance. At 80 MPH it goes up to 6,400 PSF, which yields a wopping 680,000 lbs of resistance. You are trying to move 340 tons of air when driving at that speed so you will burn some serious fuel at 80 MPH. Many drivers report that they will see a 1 MPG difference for every 10 MPH at highways speeds so driving 55 versus 75 will take you longer to get there but you'll make less trips to the bank to withdraw fuel money.
Also, keep in mind that a 20 MPH headwind when driving at 60 MPH is the same thing as driving at 80 MPH with no headwind.