Matt, I've seen people who store a small, tackle box-sized tool box in there, but only a light weight box should go in there. I have my multi-drawer tool box in the compartment just forward of that area. It sits E/W towards the front, facing rearward, backing up against the slide in the compartment just forward of that area.
I wanted to apply as much weight as possible to the rear wheels, since the critical loadings are always on the front axle in most all coaches.
2014 Newmar Essex 4544
2007 Lexus LX470 Toad