Yes we have to pull in the opposite way, but haven't encountered it being a big issue for us.
I can offer this, on the last bay on the PS of the Anthem, I store 2 of the 2.5 gallon DEF containers that you can buy at the truckstop/Wal-Mart. They fit into the space perfectly. We buy the DEF at truckstops as it's much cheaper. When I get low, I use the 2.5 containers and just refill them when are at a truckstop refilling the DEF tank. It's nice to have the reserve DEF; as stated above 5 gallons will get you quite a few miles.
2013 Entegra Anthem 44 DLQ