We've been in our 2013 Anthem DEQ or 3.5 months and love it...you'll be very pleased if you looking for a floor plan with this type of entertainment center living area. To answer your questions, IMHO:
1) We pull a F-150 with a long bed, specifically to haul a Harley Ultra Classic. We use a Big Boy ramp which we also haul in back. Total weight with the bike, ramp and other stuff: about 7500 lbs (we use a roadmaster Blackhawk II toe bar). I don't know your engine, but we've pulled this system with the 450 with no issues in the mountains in NM. It also pulls long grades well, using economy mode rarely shifts out of 5th gear (6th being the road gear). Biggest issue is we see a drop of about .5 to .75 MPG when pulling the F-150 with bike on board. I don't know your engine, but weight and the Anthem's torque and HP should not be a problem.
2) The Select Comfort states clearly, and we we're told to deflate to "10%" when driving in changing elevations. I do 55-65 and we forgot going into NM. The bed got pretty "hard". Reality is we were lucky that we didn't develop a leak. Now deflate on departure some, depending on the elevations we'll be driving.
3) Making the bed. On the rear side, you are standing on an 8 inch higher platform. so you have to bend over a bit. Room on the forward side on the floor to reach to do the top of bed. The mattress slides back and forward about 1.5 inches allowing you to tuck the sheet and overs from each side as you make.
4) We basically leave the L shaped couch in and when slides are out, I move the Euro-recliner to the space where the couch would come out. That's just my personal preference. I use footstool to prop feet up as I'm too long for recliners on the chair or couch. Spouse prefers swinging the passenger lounge around and the Boston owns the couch.
Bottom line, love the coach, love the customer service. As with all new coaches, we have a few things we're working, but fit and finish combined with amenities, customer service, and warrantee say this coach is a best buy at the price point...and we looked at a lot.