As somebody who does that drive multiple times a year and has for decades, there's no 'best roads'.
There's I-90 to I-79 to I-77 to I-26 to I-95 to I-4, shorter, quicker, more scenic but mountainous. Lots of stretches of little to no built-up areas, just the usual services at exits.
Then there's I-90 to I-71 to I-75. Much flatter, runs through more built-up areas. Also a lot longer and slower and routes you through several metropolitan areas notorious for traffic congestion.
If you want to take your time and smell the daisy's there's a myriad of secondary highways that will get you there too, but at the expense of time and may be a challenge with a bigger rig since they're often narrower winding roads that go through the center of many smaller towns.
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Ted 'n' Laurie, plus Jackson (aka Deputy Dog, the Parson Russell Terrier 'fur kid') and, Rylie (who crossed the Rainbow Bridge June 14, 2012).
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