Been to Florida from OKC quite a few times over the years, and a couple of years ago we took the motorcycle and it took us six days to get to Orlando. More than ready to do that again.
Unless I'm travelling through the Big D at 4am, I avoid it like my mother-in-law. Sometimes we'll cut east at Gainesville (82), then turn it south on 69 till we get to I-20. takes a little more time, but less headache, and it's not the interstate.
After that, it's east to shreveport, south to lafayette, then back east on I-10 to cross the long swamp bridge because the kids and wife think it's cool.
We often take the first exit in Mississippi and take 90 for our first taste of salty air. There are also a few good spots to pull over and jump in the water along that route.
On our motorcycle adventure, we took the ferry across Mobile Bay. There are old forts on either side of the bay that make for a fun distraction.
After that, we find our way to 98 for a tour of the coastal towns in Florida. 30a through Watercolor is an interesting side trip along the way. Panama City Beach has a good spot or two to pull over and get wet.
Depending on our timetable, we'll either take 98 all the way through Perry, or head back north to I-10 once we hit Panama City.
The interstate is never too awful far away from 98 if you lose track of days and find a need to make up some time.