I would restrict my travel to between the hours of 9 am and 2 pm. Get on either side of those hours and you are in rush hour traffic.
I have traveled thru there by going west on 495, east on 495, 395 to 295 (BW parkway), and a couple of others that don't warrant mention. I haven't found much difference in travel time regardless of route.
Personally, I usually take 95 to 495 east (beltway) and then pick up 95 north again off of that.
2005 Newmar KSDP 3910
ISC on a Spartan