287 to I-80 to US 95. Be sure to fuel in Winnemuca, then north to SR 78 to US 20 to Bend. There is a lot of empty country north of Winnemuca. Top of your fuel in Winnemuca. I have not
traveled SR 78 but it looks like a most direct route to US 20 at Burns, OR then west to Bend.
driven SR 140 from the junction with US 95 to US 395. It was a good 2 lane, lightly traveled, highway through more empty country. There is one fairly steep downhill of at least 5 miles when westbound.
We love to tour through open country and small towns so we would not hesitate to use either of these choices.
Have a great trip. Safe travels.