The "best" route always depends on what set of preferences you apply. some folks just want the fastest from A to B, some want scenery & interesting stops along the way; some prefer interstate freeways, some do everything to avoid interstates, etc.
The obvious route options seem to be: US72 to 157 to 36 to 231.
or if you prefer some limited access interstate I-22 to US278, a few more miles but at higher speeds & fewer towns to pass through, it may be the same driving time. take your pick