If you don't mind interstates and cities ... then Kansas City, MO to Lincoln, NE then west on I-80 (you can take NE-2) from I-29 to Lincoln
If you want to travel other routes ... then US-81 is a very good road through Kansas and Nebraska for north-south travel. For westerward travel through Nebraska and Wyoming you could take US-34 (just north of York, NE) to Grand Island ... then pick up US-30 all the way to Laramie
2004 Winnebago Journey 39W - 2012 Buick Enclave
Present @home Home: Oshkosh, WI
We call our rig "Ernie the Journey"