Depending where your ultimate destination is, head up to Reno, then take 395 south toward Bishop...beautiful drive. Otherwise, head down toward Mojave and go across to 395. Just made that trip, both routes in May. Other routes - like Tioga Pass - may be closed due to weather...best to check first. Weather could hit the Reno I-80 route - if so, then south through Mojave to 395 is the best bet. Hope that helps.
Joe and Debbie, Emma the Aussie Cattle Dog who adopted us
2012 Discovery 36J, Blue Ox and Air Force One, 2010 GMC Acadia Toad
USAF (Ret) WDØM http://wd0m.com