Last year we traveled from Branson back to north Georgia by taking Hwy 65 North to Hwy 60 East out of Springfield. This is a 4 lane route across southern Missouri all the way to I-55. From there I would take I-55 to Memphis and I-22 down to Birmingham. Then take I-65 through Montgomery and the I-10 over toward Destin. If you opt for this route there's a little trick to bypass congestion in south Memphis trying to transition from I-55 to I-22. You follow I-55 South around Memphis and into Mississippi exiting I-55 at Miss Hwy 302 or Goodman Rd. Follow Goodman Rd. east towards Olive Branch and pick up I-22 South there.
Steve n' Tammy with Ella Mae the "Shippet" in a 2003 Fleetwood Bounder 32' on a Ford F53 Chassis and a V-10 gasser pulling a 2013 Ford Edge on a EZE Tow Dolly