What are you driving? Be aware that CA 1 along the Big Sur coast has size limitations. And I would suggest avoiding taking 1 through San Francisco to connect with 80 east to Reno because traffic on city streets in SF is always a pain.
If you want to follow the coast as much as possible, you can take CA 1 all the way north to Half Moon Bay, and then cut east on 92. You could then take 101 north to 80, or continue east on 92. If you choose that option, once you cross the bay, you have the can either takie 880 north to connect with 80, or travel further east on 580 to 680, and then up to 80. There is not usually a huge time advantage with any of the options, because distance vs. traffic tend to cancel each other out.
Oh, and going east across the Bay Bridge (80) or San Mateo Bridge (92) is free, but going east on the Carquinez Bridge (80) or Bencia Bridge(680) is the toll direction.
Have a great trip!
Just the two of us, and Falkor, the 2015 Ford 350 Dually, pulling a 2016 39R12 Vengeance Touring Edition Toy Hauler, with a Can-Am Spyder RT