I-70 is a good route. Through the CO mountains, you can - possibly - encounter snow in October. Be sure to check the weather. Through Denver, I-70 can be slow going. There will be construction ongoing there as well.
Lots of places are available just off I-70. Start with the James Cobb State Park in Fruita, CO, just off the interstate, then gauge your travel times through Colorado, and you'll find the rest.
Hope that helps - a bit.
Joe and Debbie, Emma the Aussie Cattle Dog who adopted us
2012 Discovery 36J, Blue Ox and Air Force One, 2010 GMC Acadia Toad
USAF (Ret) WDØM http://wd0m.com