I have driven up 41A east bound out of Cowan Tn. into Monteagle, slowly, with no issues. It is a beautiful drive going up. I'm sure you can go down and enjoy as well. It's very nice from where the St Hwy 56 cuts off down into Cowan. Take your time to enjoy the view.
Now if you are talking about 41 going to Pelham there is one real tight turn but if a semi can do it you should be fine.
For sightseeing I think 41A into Nashville is better.
Steve n' Tammy with Ella Mae the "Shippet" in a 2003 Fleetwood Bounder 32' on a Ford F53 Chassis and a V-10 gasser pulling a 2013 Ford Edge on a EZE Tow Dolly