Take the Loneliest Highway in America
Lots of options for you to choose from.
I really like the drive west on US Hwy 50 from Grand Junction. It's pretty, relaxing, and a great drive to Carson City. If you'd like to see Tahoe, it's just a hop, skip, and a jump away. From there you can pick up I-80 West and take CA Hwy 20 through Yuba City over to I-5 North up to Redding. From there, take CA Hwy 299 over to the 101 North into the park.
Have a great trip and be sure to let us know what you think!