Recently, we traveled I-10 west through many fine and large cities. But, I took advice from the "panel of experts"
on this site and went through Houston on a Sunday morning at 8:00am. Got through this sprawling and BIG city at the posted speed limit with relatively light traffic in about 40 minutes! Wow.. this is a big city with MAJOR highways. I counted as many as nine (9) lanes wide on my side alone at times.
I can only imagine what rush hour may be like.
Anyway, early Sunday morning is good travel advice for any large city.
BTW - I'm always impressed with the absolutely beautiful civil engineering and aesthetic SW design themes on the bridge works in the southern states.... stunning!