I live not far from I-81 in Virginia. It is not a bad highway, but has lots of semi traffic. You can take I-81 to I-66 to US-17 to I-95, or I-81 to I-64 to I-95, or I-81 to I-77 to I-26 to I-95. Using I-64 will be longer by a couple of hours. I-81 is in the mountains and you need to keep a close eye on the weather. What might be rain on I-95 could very well be snow on I-81. The trip on I-81 is much more scenic than I-95. Hope this helps.
2011 Fleetwood Expedition
2014 Chevy Traverse