I live in Ohio and snowbird the slightly western route. Cincinnati is not a problem since I use the eastern outer belt (I forget the number ) and traffic is better. I then go over to Louisville and catch a beltway around to I-65 south. The next problem is Nashville, and I don't know an easy answer, so we stop there overnight, and start out fresh in the morning. The northern bypass around Montgomery, Alabama takes me to route 231, and the next overnight for us is around Ozark. From there it's down to I-10 and east into the Florida peninsula.
I know that it's a little longer, but it's a more friendly drive for us. Many travel I-75, but as mentioned Atlanta is a worry, and for me that mountain just north of Knoxville, ( Jellico ) is a worry from this time of year forward. I've already driven on dry roads in Kentucky, and got to the top of Jellico to find icy roads and snow.
And I find the traffic on I-65 to be lighter, in general, so I can relax and enjoy the trip.
Let me know if you would like more details.
2003 Rexhall Rexair, 3550 Ford V10 with Banks
2014 Honda CRV-AWD via Blue Ox
Travel with SWMBO and Golden Doodle co pilot