This looks like the most direct route. My brother came from the Columbus, Ohio area across I 70 to St louis, I 270 to I 44 to Springfield and then on down 65 to Branson when we made our trip up in June.. There was 3 vehicles traveling together , don't remember where they stayed for the night. Be sure to take one of the 'outer' routes around downtown..to miss all the traffic on the main street, depending on where you will be staying.. We were on the Blue Route from the north side of Branson that took us to the West side and then on south to our campground. We stayed at Ozark Mountain Campground and highly recommend it.. lots of trees..
Enjoy your time in Branson.. so much to do and see!!! for all ages
& Slowpoke, USMC [1993 Gulfstream Sunvoyager M8345, F53 Chassis ]
"Travlin with a song and prayer"