Denver I do not know about but in October you *SHOULD* be OK,,, The key word is SHOULD, less something happens, (And remember I don't know Denver)
I took a slightly different route in 2006 leaving Detroit, MI on the evening of the Tuesday before Thanksgiving... I made it with only one minor disaster (Froze up in Wyoming, thawed in Utah, broke one fitting, repairs <$10.00) but I wished to go via Pender, and Lincoln NE..
IN October, outside of Denver, I would not expect any nasty stuff,, but surprises happen.
Home is where I park it!