First off welcome to iRV2 & the great RV lifestyle! I think one of the best things to do, even if you have a maping program or GPS with you is to also have a good paper Road Atlas! Another route for you is I-90E to I-390 to I-86 to I-81S to I-64E to I-295 to I-95S to US-301 to US-501 into Myrtle Beach ! Also your time limit has a lot to do with picking a route, as well as what type of roads you like to travel! Even though I am retired and take my time I still like to travel on certain interstates for finding lots of places that are easy to get in and out of for gas, food or overnight stay! Hope this helps some and enjoy & have a safe trip no matter what route you take!
AL, & Mickey "The Boston"! Silver Springs, FL Camping since 1967 and RVing since 1990! A 2011 Keystone Hornet 30RKDS & 2015 Yamaha V-Star 1300 Delux WATCH FOR MOTORCYCLE