I run from Charleston to Knoxville fairly often and that is what I would suggest. You will have one grade on I-26 coming up Saluda Mtn but it is not a big deal then I-40 goes through, rather than over, the mountains. My main reason for the suggestion is I'd rather go up I-75 from Knoxville than go I-77 thru WV.
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Larry, Beverly & Pat
Pups - Romeo, Teddy Bear, Frankie
2013 Thor Tuscany, 45', Freightliner chassis, Cummins ISL10, towing a Buick Enclave
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