We had severe flooding and closures along Rt. 90 Albany to Syracuse and Rt. 81 south to the PA. line. However, both are open now and the weather forecast is good, some on off ramps may remain closed but that should not present a problem.
Here is a link with up to date info:
AVOID Rt.88. If you are looking at maps it would be the route to take southwest out of Albany to Binghamton but they had all four lanes wash out in Sidney, that's where the two truckers, one in each direction drove off the ends of the highway and died.
Have a safe one and if you choose the 90 / 81 route, toot as you past through the Syracuse area we'll