We have traveled to Goshen from SC three times. Although 33 and 35 are pretty good roads, it seems to us that they make Ohio an extremely large state.
I personally like the route taking the interstates. Since I live in northern SC, I usually take US 74 over to I-26 to I-40 over to Knoxville and pick up I-75. There was considerable delaying construction in Louisville last fall, so I would go on up to Cinncinatti, then take I-74 to Indy. From there north on US 31, with a route through Nappanee to Goshen. As I remember there was also some bridgework south of Goshen that also caused a detour.
While in Goshen, I recommend a day trip over to Shipshiwanna, to visit the Amish in the flea market and shop at Yoder's Meat and Cheese.
Bob & Rita
2014 Thor Palazzo 33.2
2010 Chevy Colorado toad