We did this the last week of Oct last Fall. Stayed overnight at Loft Mountain Campground. There are absolutely no issues for a 40' coach.
The consensus on these forums was that the drive and campgrounds would be packed because of prime leaf season but the campgrounds had lots and lots of room and the drive was very lightly traveled.
A couple photos from last Fall are below.
In 3 weeks we're driving the complete Blue Ridge Parkway on our way to FL for the winter.
-Tom
Driving out of the tunnel.
Loft Mountain Campground
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Sarver, PA/Crystal River, FL/Shelocta, PA · FMCA 335149 · W3TLN
2005 Suncruiser 38R · W24, no chassis mods needed · 2013 Honda Accord EX-L · 2008 Honda Odyssey EX-L