Cut southeastward through Ohio on some US Highways. I've found those to be pretty good roads throughout the Midwest. Pick up I-77 south to I-81 south, then I-26 toward Asheville. At Asheville take I-40 west to where US74 branches off about 20 miles west of Asheville. From there I don't know the roads. US 19 through Maggie Valley is more direct to Cherokee, but may be a bit snug for some RVs. Someone will chime in.
John & Diane, fulltiming since '12
'02 DS, FL, Cat, '04 Element
John & Diane, Fulltimers. RVM103 NHSO
On the road since June '12 with Lincoln, the guard cat.
2002 Dutch Star 40, Freightliner, Cat 3126, 2004 Element