I have travelled from Cheyenne through Iowa many times.
Places to see as you travel I-80:
If you are a train buff a) In Cheyenne there is an enormouss steam engine in the city park just east of downtown on Lincolnway and b) just west of North Platte, NE there is a gigantic high tech switching facility
If you like Sports business: there is a a great store (and campground) at Cabella's in Sidney, Nebraska
There are two great public campgrounds along I-80 in central Nebraska ... one at the Gibbon exit (Windmill rec area) and one at Grand Island interchange (Mormon Island) ... both have sites that you can treat as pull throughs ... we stay there as often as possible
At Kearney, NE there is a great museum of the westward expansion of the United States ... plan on at least 2 hours for this ...
You can avoid downtown Omaha and Council Bluffs by taking I-680 (it is about 10 miles further but worth it in my opinion)
You will most likely encounter orange barrels ... the traffic is squeezed down to a single lane but the traffic generally moves along nicely. There are lots of 18 wheelers on I-80 east of Ogallala, NE to Chicago.
2004 Winnebago Journey 39W - 2012 Buick Enclave
Present @home Home: Oshkosh, WI
We call our rig "Ernie the Journey"