This is a lot easier now that 22 ends at Coalburg road (it does not connect to 65 directly yet) so stay on 22 until the very end when you have to get off (do not get off at 78).
Go right at the top of the off ramp (south) on Coalburg for about a mile or so, and then left (east) at the first light which is Daniel Payne Road, which leads you to 65 which is less than a 1/2 mile.
There is a Flying J where Daniel Payne mets 65 if you need a stop / fuel.
The 65 south / 20 east interchange is tricky, and if I remember correctly you have to be in the left lanes on 65 south to make the transition to 20 east. And 20 in downtown Birmingham is tight and very busy, and you need to pay close attention to speed and lanes.
20 from Birmingham to Atlanta is very heavy with big rigs during the week, so it's not a fun drive either, so if you can do it on a weekend it is a much less stressful drive.
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