Assuming you have checked the weight capacities of the truck, and picked a 5th wheel trailer that is suitable, just take it slowly until you get the feel for the set-up. You are an experienced big RVer, so you know to watch mirrors. You just have to swing that truck wider than normal, like a tractor-trailor rig. I asked my dealer before my purchase to drive it over (his truck) to make sure it would back-in to my driveway OK. I went from a 21' trailer to a 33' 5th wheel with a quick and easy learning curve. As mentioned above, the height is the thing I have to be most concerned with (you're already used to the height clearance concerns).
A proper quick, brave, steady, ready gentleman!
2011 PALOMINO SABRE SILHOUETTE 260BHS