Well there are some desolate areas but if you stay on the interstate there's allways at least a gas station every couple hundred miles, this is the United States of America, not uncharted territory, lol! If there's a paved 4 lane your never too far from 24 hour services, if you start getting on 2 lanes you can find yourself stuck in small towns that roll up the sidewalks and don't take credit cards and might be stuck there till Monday if your fuel tank is low, lol!
Whats your fuel capacity/range? My 350 only has a 26 gal tank which pisses me off cause my f150 had 36 gal. Thinking of putting a 50 gal titan tank on it soon. There's always freeway signs telling distance to next town that I'd keep an eye on if you only have around a 300 mile or so range like I do cause the uninhabitable mountains and desserts will have 150-200 miles sometimes with no decent services and you might want to fill up at a quarter tank or more if the next towns a long ways away.
I'd have to think there would be a trip planner website of some sort if you like to plan every stop and stick to a schedule which some people enjoy and would check boarderboardrs suggested one if fuel is your concern. but I like to wing it and go where I want when I want doing whatever I want with no stress of following a plan which is much better for month long or 5 month going south for the winter trips. Short trips of a week or something do require somewhat of a plan though or you just run out of time.
I'm pulling my house behind me and the only thing I need to survive really is fuel to get somewhere else to restock food water and so on. If I'm going south for the winter and I pass a sign that says worlds largest ball of twine 100 miles that way then I'm likely to take a detour cause I've got time to kill and nowhere particular I have to be which is my preferred method.