We tried a 1994 2500 Burb, 5.7L and 4.10 axle for towing a 28' Silver Streak (looks like an old Air Stream. I was not happy and we wound up keeping our 1 ton diesel dually.
The Burb was rated to pull the trailer (8500 GVWR) and it struggled on the slightest hill, it would not maintain 65 mph except on the flats and NO WIND. We got 7.2 mpg.
It would pull it, but just barely.
A higher profile like the 5er will have a lot more wind drag and be even worse on performance.
Amateur Radio Operator (KE5DFR)|Full-Time! - 2012 6.7L Ford Crew Cab Dually -2013 HitchHiker Champagne 38RLRSB - Travel with one Standard Schnauzer and one small Timneh African Gray Parrot