I would check for any delays on I40 from Knoxville to Ashville as they have been working on several areas that had landslides this last winter. There have been numerous reports of delays.
It might be better to get on 40 in Knoxville and then continue up 81 then drop off on 77 toward Wilmington.
Again, I would check on any construction delays and then make a decision.
2002 Monaco Windsor 38 PKD
2005 Jeep Grand Cherokee w/5.7 Hemi