It can be done, but you will be wiped out when you get there. We live in Southern California and almost any trip we take, it's a 500 mile drive to get out of the area and someplace decent to overnight. We don't mind doing it the first day, but for five days it will be brutal.
You may not realize it, but just paying attention to the coach, the ill effects of wind, shifting for hills, passing idiots and being passed by idiots, and constantly steering, will all take it's toll.
You're only going to average 50 mph, so take advantage of days where you can drive a little more in the evening. When you stop, make sure your companions know that you need to just relax and unwind, not deal with other issues.
Don & Mary
2014 Newmar Dutch Star - All Electric - 450 ISL
2016 GMC Canyon 4WD Crew Cab