Route 81, this time of year is luck if you miss the snow. I've traveled this road 100+ times over the decades. It just depends on how you and mother nature meet up. The big up and down to be very careful of is in the Blacksburg, VA area. Just north you'll be going down Christiansburg mountain. There are several other "hills" you'll be climbing or descending. Radford, VA, south of Christiansburg has an interesting down cross a bridge and then up. Just north of Roanoke, VA the Troutville exit is both down first then up. The little stretch in West VA and the cross over into Maryland can be tricky of there is snow or ice.
Take a laid back approach. If it is clear, count your blessings and go for it. If it is not clear weather, slow and steady will win the race.
2005 Newmar KSDP 3910 + GMC ENVOY XUV 37K lbs Moving Down The Road
The Avatar Is Many Times Around The USA
Nobody Knows Your Coach Like Somebody Who Owns One Just Like Yours