In your case (2006 W-22 Workhorse) Yes it will work or not, same as on a car of same vintage.
NOTE: I have 3 OBD-II to Blue tooth devices here
Ordered one, paired but would not connect
They shipped me a replacement.. Identical as it turns out
I ordered a more expensive one.. WORKS GREAT
The one I got is shown if you go to the Google Play store and download TORQUE FREE...Look at the OBD-II adapters and it shows a "Cheap one from E-Bay may or may not work" The one that works looks identical to that photo.
I am currently using it in my car.. (Motor home out of comission) but it also fits and reads the motor home computer just fine.
NOTE: on the Workhorse there are 2 or 3 computers.. ABS, Tranny ECU.. OBD-II may read ONLY the ECU (Engine control unit) and not the other two. Or not,, Depending more on the software I suspect. (In the computer/smart phone/tablet).
Home is where I park it!